Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation.

@article{Bijker2008SuperiorIO,
  title={Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation.},
  author={Martijn S. Bijker and Susan J. F. van den Eeden and Kees L M C Franken and Cornelis J M Melief and Sjoerd H van der Burg and Rienk Offringa},
  journal={European journal of immunology},
  year={2008},
  volume={38 4},
  pages={1033-42}
}
Anti-tumor vaccines consisting of extended CTL peptides in combination with CpG-ODN were shown to be superior to those comprising minimal CTL epitopes and CpG-ODN, in that they elicit stronger effector CTL responses with greater tumoricidal potential. We now demonstrate that this improved performance is primarily due to the focusing of CTL epitope presentation onto activated DC in the inflamed lymph nodes draining the vaccination site. In the case of vaccination with minimal peptides… CONTINUE READING

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