Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.

@article{Veldwijk1999SuperiorGT,
  title={Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.},
  author={Marlon Romano Veldwijk and Bernhard Schiedlmeier and J{\"u}rgen A. Kleinschmidt and Walter Jens Zeller and Stefan Fruehauf},
  journal={European journal of cancer},
  year={1999},
  volume={35 7},
  pages={1136-42}
}
Autologous peripheral blood progenitor cell (PBPC) grafts can be contaminated with tumour cells that potentially give rise to relapse following myeloablative therapy and PBPC transplantation. Adeno-associated virus (AAV)-based vectors produced by a new adenovirus-free technique are a gene delivery system which may be applicable for tumour cell purging. To test for the host range of these vectors, solid tumours of clinical relevance and normal CD34+ PBPC were selected as target cells for an AAV… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Gene Therapy for Sarcoma

  • S. Fruehaufa, M. R. Veldwijkb S. Berlinghoffb N. Basarac, +6 authors U. R. Henggei W. Jens Zellerb S. Laufsb
  • 2002
3 Excerpts

Similar Papers

Loading similar papers…