Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

@article{Almeida2007SuperiorCO,
  title={Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover},
  author={Jorge R. Almeida and David A. Price and Laura Papagno and Za{\"i}na Ait Arkoub and Delphine Sauce and Ethan R Bornstein and Tedi E. Asher and Assia Samri and Aur{\'e}lie Schnuriger and Ioannis D Theodorou and Dominique Costagliola and Christine Rouzioux and Henri Agut and Anne Genevi{\`e}ve Marcelin and Daniel C. Douek and Brigitte Autran and Victor Appay},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={2473 - 2485}
}
The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility leukocyte antigen (HLA)–B27 patients. To understand further the nature of CD8+ T cell–mediated antiviral efficacy, we performed a comprehensive study of CD8+ T cells specific for the HLA-B27… 

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