Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity

@inproceedings{Siegemund2012SuperiorAA,
  title={Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity},
  author={Martin Siegemund and Nadine Pollak and Oliver Seifert and Karen A Wahl and Karel Hanak and Arndt Vogel and Andreas K Nussler and D G{\"o}ttsch and Sabine M{\"u}nkel and Heike Bantel and Roland E Kontermann and Klaus Pfizenmaier},
  booktitle={Cell Death and Disease},
  year={2012}
}
Although targeting of the death receptors (DRs) DR4 and DR5 still appears a suitable antitumoral strategy, the limited clinical responses to recombinant soluble TNF-related apoptosis inducing ligand (TRAIL) necessitate novel reagents with improved apoptotic activity/tumor selectivity. Apoptosis induction by a single-chain TRAIL (scTRAIL) molecule could be enhanced >10-fold by generation of epidermal growth factor receptor (EGFR)-specific scFv-scTRAIL fusion proteins. By forcing dimerization of… CONTINUE READING
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