Superior antidepressant efficacy results of agomelatine versus fluoxetine in severe MDD patients: a randomized, double-blind study.

@article{Hale2010SuperiorAE,
  title={Superior antidepressant efficacy results of agomelatine versus fluoxetine in severe MDD patients: a randomized, double-blind study.},
  author={Anthony S Hale and Ricardo-Marcelo Corral and Claudio Mencacci and Jeronimo Saiz Ruiz and Cristina Albarran Severo and Valentim Gentil},
  journal={International clinical psychopharmacology},
  year={2010},
  volume={25 6},
  pages={305-14}
}
The objective of this international, 8-week, randomized, double-blind study was to show the superiority of the antidepressant efficacy of agomelatine, the first MT1/MT2 receptor agonist and 5-HT2C receptor antagonist antidepressant, versus fluoxetine in outpatients fulfilling Diagnostic and Statistical Manual of Mental Disorders-volume IV-TR criteria for major depressive disorder of severe intensity, defined by a baseline Hamilton Depression Rating Scale (HAM-D17) total score of at least 25 and… CONTINUE READING
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