Superior Survival in Treatment of Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity

@article{Wilkins2003SuperiorSI,
  title={Superior Survival in Treatment of Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity},
  author={Ross M. Wilkins and John W. Cullen and Lorrie Furman Odom and Brandt A. Jamroz and P. Cullen and Kyle Fink and Sanford D. Peck and Sidney L Stevens and Cynthia M. Kelly and Anne B Camozzi},
  journal={Annals of Surgical Oncology},
  year={2003},
  volume={10},
  pages={498-507}
}
Background: A protocol to treat osteosarcoma of the extremity was developed at two local institutions.Methods: The study involved a dose-intensified neoadjuvant protocol of intravenous doxorubicin and intra-arterial cisplatin administered repetitively until maximum angiographic response was noted. Definitive surgery was delayed until ≥90% reduction in tumor neovascularity was documented. Prospective assessment of serial arteriograms was highly accurate (94%) in predicting histological response… 
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