Superior Solubility and Dissolution of Zaltoprofen via Pharmaceutical Cocrystals

@article{Panzade2019SuperiorSA,
  title={Superior Solubility and Dissolution of Zaltoprofen via Pharmaceutical Cocrystals},
  author={Prabhakar Panzade and Giridhar R. Shendarkar},
  journal={Turkish Journal of Pharmaceutical Sciences},
  year={2019},
  volume={16},
  pages={310 - 316}
}
Objectives: Pharmaceutical cocrystals are a promising tool to enhance the solubility and dissolution of poorly soluble drugs. Zaltoprofen (ZFN) is nonsteroidal anti-inflammatory drug with a prevalent solubility problem. The present study was undertaken to enhance the solubility and dissolution of ZFN through pharmaceutical cocrystals by screening various coformers. Materials and Methods: Cocrystals of ZFN were prepared in 1:1 and 1:2 ratio of drug:coformer by the dry grinding method. The… 

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References

SHOWING 1-10 OF 33 REFERENCES
Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation
TLDR
The piroxicam cocrystal with modified properties was prepared with sodium acetate and formulated as orodispersible tablets having faster disintegration and greater dissolution rate.
Crystal engineering to improve physicochemical properties of mefloquine hydrochloride
TLDR
Cocrystals resist the conversion of anhydrous form of drug into its hydrate which is responsible for the drugs less solubility and dissolution rate.
Pharmaceutical Cocrystals: An Overview
Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient are the major constraints during the development of new product. Various approaches have been used for
Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds
TLDR
Cocrystallizations of exemestane and megestrol acetate from cocrystallization using various particle sizes improved initial dissolution rates compared to the respective original crystals.
Small-Scale Assays for Studying Dissolution of Pharmaceutical Cocrystals for Oral Administration
TLDR
Improved dissolution and useful insights into precipitation kinetics of poorly soluble compounds from the cocrystal form can be revealed by the small-scale dissolution assay.
Pharmaceutical Cocrystals of Niclosamide
Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such as caffeine (CAF), urea (URE),
Physico-mechanical and Stability Evaluation of Carbamazepine Cocrystal with Nicotinamide
TLDR
The preformulation profile of the cocrystals was similar to CBZ, except that it had an advantageous resistance to hydrate transformation, as revealed by the stability studies.
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.
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