Superior Solubility and Dissolution of Zaltoprofen via Pharmaceutical Cocrystals

  title={Superior Solubility and Dissolution of Zaltoprofen via Pharmaceutical Cocrystals},
  author={Prabhakar Panzade and Giridhar R. Shendarkar},
  journal={Turkish Journal of Pharmaceutical Sciences},
  pages={310 - 316}
Objectives: Pharmaceutical cocrystals are a promising tool to enhance the solubility and dissolution of poorly soluble drugs. Zaltoprofen (ZFN) is nonsteroidal anti-inflammatory drug with a prevalent solubility problem. The present study was undertaken to enhance the solubility and dissolution of ZFN through pharmaceutical cocrystals by screening various coformers. Materials and Methods: Cocrystals of ZFN were prepared in 1:1 and 1:2 ratio of drug:coformer by the dry grinding method. The… 

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