Superinduction of IL-2 gene transcription in the presence of cycloheximide.

  title={Superinduction of IL-2 gene transcription in the presence of cycloheximide.},
  author={Ana M. Zubiaga and Eduardo Mu{\~n}oz and Brigitte Huber},
  journal={Journal of immunology},
  volume={146 11},
Lymphokine production is regulated both at the transcriptional and the posttranscriptional level. To date, it has been shown that the protein synthesis inhibitor cycloheximide (CHX) up-regulates IL-2 expression in T cells by stabilizing its mRNA. In this report we have examined the effect of CHX on IL-2 at the transcriptional level. We have found that CHX has a positive regulatory function in IL-2 transcription, which is dependent on prior activation of this gene. This is not due to… CONTINUE READING

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