Superhydrophobic silica nanoparticles as ultrasound contrast agents.

  title={Superhydrophobic silica nanoparticles as ultrasound contrast agents.},
  author={Qiaofeng Jin and Chih-Yu Lin and Shih-Tsung Kang and Yuan-Chih Chang and Hairong Zheng and Chia-Min Yang and Chih-Kuang Yeh},
  journal={Ultrasonics sonochemistry},
Microbubbles have been widely studied as ultrasound contrast agents for diagnosis and as drug/gene carriers for therapy. However, their size and stability (lifetime of 5-12min) limited their applications. The development of stable nanoscale ultrasound contrast agents would therefore benefit both. Generating bubbles persistently in situ would be one of the promising solutions to the problem of short lifetime. We hypothesized that bubbles could be generated in situ by providing stable air nuclei… CONTINUE READING