# Superfamilies of Evolved and Designed Networks

@article{Milo2004SuperfamiliesOE, title={Superfamilies of Evolved and Designed Networks}, author={Ron Milo and Shalev Itzkovitz and Nadav Kashtan and Reuven Levitt and Shai Shen-Orr and Inbal Ayzenshtat and Michal Sheffer and Uri Alon}, journal={Science}, year={2004}, volume={303}, pages={1538 - 1542} }

Complex biological, technological, and sociological networks can be of very different sizes and connectivities, making it difficult to compare their structures. Here we present an approach to systematically study similarity in the local structure of networks, based on the significance profile (SP) of small subgraphs in the network compared to randomized networks. We find several superfamilies of previously unrelated networks with very similar SPs. One superfamily, including transcription…

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