Supercritical fluid chromatography for the enantioseparation of pharmaceuticals.

@article{Klerck2012SupercriticalFC,
  title={Supercritical fluid chromatography for the enantioseparation of pharmaceuticals.},
  author={Katrijn De Klerck and Debby Mangelings and Yvan Vander Heyden},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2012},
  volume={69},
  pages={77-92}
}
Chirality has a significant impact on drug discovery and development processes in the pharmaceutical industry. As the number of enantiopure drugs launched onto the market is yearly increasing, the need for fast and performant enantioseparation methods with minimal costs is becoming more compelling. In this context, sub- and supercritical fluid chromatography (SFC), being applicable at an analytical, as well as at a preparative scale is gaining more interest. In this review a practical overview… CONTINUE READING

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