Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex formation.

@article{Moribe2008SupercriticalCD,
  title={Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex formation.},
  author={Kunikazu Moribe and Yuichi Tozuka and Keiji Ibaraki-shi Yamamoto},
  journal={Advanced drug delivery reviews},
  year={2008},
  volume={60 3},
  pages={
          328-38
        }
}
Supercritical fluid technique have been exploited in extraction, separation and crystallization processes. In the field of pharmaceutics, supercritical carbon dioxide (scCO(2)) has been used for the purpose of micronization, polymorphic control, and preparation of solid dispersion and complexes. Particle design of active pharmaceutical ingredients is important to make the solid dosage forms with suitable physicochemical properties. Control of the characteristic properties of particles, such as… CONTINUE READING
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