Supercritical CO2 generating chitosan devices with controlled morphology. Potential application for drug delivery and mesenchymal stem cell culture

@inproceedings{Silvaa2008SupercriticalCG,
  title={Supercritical CO2 generating chitosan devices with controlled morphology. Potential application for drug delivery and mesenchymal stem cell culture},
  author={L{\'i}gia M.C. Silvaa and Pedro Z. Andradeb and Francisco dos Santosb and Cl{\'a}udia Lobato da Silvab and oaquim M.S. Cabralb and Manuel M A Abecasis and Ana Aguiar-Ricardoa},
  year={2008}
}
  • Lígia M.C. Silvaa, Pedro Z. Andradeb, +4 authors Ana Aguiar-Ricardoa
  • Published 2008
In this work, a novel approach involving supercritical carbon dioxide (scCO2) induced phase inversion technique was developed to produce chitosan devices using moderate temperatures and three very environmentally acceptable solvents (water, ethanol and CO2). The morphology and three-dimensional (3D) structure were controlled by altering the co-solvent (ethanol) composition in the carbon dioxide nonsolvent stream during the demixing induced process. Microarchitectural analysis by scanning… CONTINUE READING
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