Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3

  title={Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3},
  author={Muhammad Azhar Sherkheli and Guenter Gisselmann and H. Hatt},
Transient receptor potential vanilloid subtype 3 (TRPV3) is a thermosensitive ion channel expressed in a variety of neural cells and in keratinocytes. It is activated by warmth (33-39°C), and its responsiveness is dramatically increased at nociceptive temperatures greater than 40°C. Monoterpenoids and 2-APB are chemical activators of TRPV3 channels. We found that Icilin, a known cooling substance and putative ligand of TRPM8, reversibly inhibits TRPV3 activity at nanomolar concentrations in… CONTINUE READING


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