Superbases for organic synthesis

@article{Schlosser1988SuperbasesFO,
  title={Superbases for organic synthesis},
  author={Manfred Schlosser},
  journal={Pure and Applied Chemistry},
  year={1988},
  volume={60},
  pages={1627 - 1634}
}
  • M. Schlosser
  • Published 1988
  • Chemistry
  • Pure and Applied Chemistry
A review with 70 refs. LICKOR mixts. of organolithium reagents and bulky potassium alcoholates allow the smooth metalation and subsequent electrophilic substitution of low acidity hydrocarbons, in particular olefins. The allylpotassium intermediates exhibit peculiar conformational preferences which can be exploited in novel stereoselective carbon-carbon linking reactions. A few syntheses of simple natural products illustrate the method. A tentative explanation is given for the superior… Expand
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  • Medicine, Chemistry
  • Chemistry
  • 2020
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