Superantigens of mouse mammary tumor virus.

  title={Superantigens of mouse mammary tumor virus.},
  author={Hans Acha-Orbea and Heather R Macdonald},
  journal={Annual review of immunology},
Superantigens (SAgs) are proteins of microbial origin that bind to major histocompatibility complex (MHC) class II molecules and stimulate T cells via interaction with the V beta domain of the T cell receptor (TCR). Mouse mammary tumor virus (MMTV) is a milk-transmitted type B retrovirus that encodes a SAg in its 3' long terminal repeat. Upon MMTV infection, B cells present SAg to the appropriate T cell subset, which leads to a strong "cognate" T-B interaction. This immune reaction results in… CONTINUE READING