Superantigens and nasal polyps.

  title={Superantigens and nasal polyps.},
  author={C Bachert and Thibaut P J van Zele and P Gevaert and Lore De Schrijver and Paul van Cauwenberge},
  journal={Current allergy and asthma reports},
  volume={3 6},
Nasal polyps represent an often severe T-cell-orchestrated eosinophilic upper airway disease with currently unknown pathogenesis, often associated with lower airway disease, such as asthma. Superantigens, predominantly derived from Staphylococcus aureus, are potent activators of T cells, induce the synthesis of IgE in B cells, and have direct effects on pro-inflammatory cells, such as eosinophils. IgE antibodies to S. aureus enterotoxins have been described in polyp tissue, linked to a local… CONTINUE READING