Superantigens and chronic rhinosinusitis: detection of staphylococcal exotoxins in nasal polyps.

@article{Seiberling2005SuperantigensAC,
  title={Superantigens and chronic rhinosinusitis: detection of staphylococcal exotoxins in nasal polyps.},
  author={Kristin A Seiberling and David B. Conley and Anju Tripathi and Leslie C. Grammer and Lydia Shuh and G. Kenneth Haines and Robert P. Schleimer and Robert C. Kern},
  journal={The Laryngoscope},
  year={2005},
  volume={115 9},
  pages={1580-5}
}
OBJECTIVE/HYPOTHESIS The role of infectious agents in the etiology of chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear. Recent studies have provided indirect evidence of exposure to staphylococcal exotoxins in the blood and polyp tissue of patients with CRSwNP. These exotoxins have the capacity to act as superantigens, bypassing normal antigen processing and directly stimulating a massive inflammatory response. The objective of the study was to analyze mucus and polyp tissue… CONTINUE READING