Superantigenic properties of the group A streptococcal exotoxin SpeF (MF).

  title={Superantigenic properties of the group A streptococcal exotoxin SpeF (MF).},
  author={Anna Norrby-Teglund and Danette Newton and Malak Kotb and Stig E. Holm and Mari Norgren},
  journal={Infection and immunity},
  volume={62 12},
Streptococcal pyrogenic exotoxin F (SpeF), previously referred to as mitogenic factor, is a newly described potent mitogen produced by group A streptococci. To investigate whether this protein belongs to the family of microbial superantigens, we analyzed the cellular and molecular requirements for its presentation to T cells and compared it with the known streptococcal superantigen pyrogenic exotoxin A (SpeA) and the nonspecific polyclonal T-cell mitogen phytohemagglutinin (PHA). SpeF and SpeA… CONTINUE READING
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