Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation

@inproceedings{Turner2012SuperantigenicAO,
  title={Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation},
  author={Claire E Turner and Mary Sommerlad and Karen McGregor and Frances J. Davies and Bruno Pichon and Deborah L. W. Chong and Leili Farzaneh and Matthew T. G. Holden and Brian G. Spratt and Androulla Efstratiou and Shiranee Sriskandan},
  booktitle={PloS one},
  year={2012}
}
Streptococcus pyogenes M/emm3 strains have been epidemiologically linked with enhanced infection severity and risk of streptococcal toxic shock syndrome (STSS), a syndrome triggered by superantigenic stimulation of T cells. Comparison of S. pyogenes strains causing STSS demonstrated that emm3 strains were surprisingly less mitogenic than other emm-types (emm1, emm12, emm18, emm28, emm87, emm89) both in vitro and in vivo, indicating poor superantigenic activity. We identified a 13 bp deletion in… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-5 of 5 citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Association of smeZ alleles and emm types in a collection of Streptococcus pyogenes from the United Kingdom

  • K McGregor, B Spratt, H Russell, S Sriskandan
  • Abstract: Lancefield International Symposium on…
  • 2005
Highly Influential
4 Excerpts