Superantigen responsive T cells are required for nasopharyngeal infection by Streptococcus pyogenes

@inproceedings{Zeppa2017SuperantigenRT,
  title={Superantigen responsive T cells are required for nasopharyngeal infection by Streptococcus pyogenes},
  author={Joseph J Zeppa},
  year={2017}
}
Streptococcus pyogenes is a human-specific pathogen that is responsible for serious morbidity and mortality worldwide despite being susceptible to common antibiotics. Furthermore, there is currently no licensed vaccine available against this organism. Previous research from our laboratory implicated a critical role for superantigens in a transgenic mouse model of acute nasopharyngeal infection by S. pyogenes. Herein, we are able to detect superantigen production in vivo and establish that anti… CONTINUE READING

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