Superantigen bacterial toxins: state of the art.

@article{MllerAlouf2001SuperantigenBT,
  title={Superantigen bacterial toxins: state of the art.},
  author={Heide M{\"u}ller-Alouf and Christophe Carnoy and Michel Simonet and Joseph E. Alouf},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2001},
  volume={39 11},
  pages={
          1691-701
        }
}
Superantigens (SAgs) are viral and bacterial proteins exhibiting a highly potent polyclonal lymphocyte-proliferating activity for CD4(+), CD8(+) and sometimes gammadelta(+) T cells of human and (or) various animal species. Unlike conventional antigens, SAgs bind as unprocessed proteins to invariant regions of major histocompatibility complex (MHC) class II molecules on the surface of antigen-presenting cells (APCs) and to particular motifs of the variable region of the beta chain (Vbeta) of T… CONTINUE READING
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