Superactivation of integrin alphavbeta3 by low antagonist concentrations.

  title={Superactivation of integrin alphavbeta3 by low antagonist concentrations.},
  author={Daniel F Legler and Guido Wiedle and Frederick Ross and Beat Albert Imhof},
  journal={Journal of cell science},
  volume={114 Pt 8},
Integrins are implicated in cell adhesion, migration and homeostasis. An important feature is their ability to adopt different affinity states that can be regulated by a variety of intra- and extracellular factors. To study affinity modulation of the integrin ectodomain by extracellular factors, we produced a soluble recombinant form of mouse integrin alphavbeta3 in a mammalian expression system and isolated it to purity. We show that the two transmembrane truncated integrin subunits stably… CONTINUE READING
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