Superactivation of an immune response triggered by oligomerized T cell epitopes.

@article{Roetzschke1997SuperactivationOA,
  title={Superactivation of an immune response triggered by oligomerized T cell epitopes.},
  author={Olaf Roetzschke and Kirsten Falk and Jack Leonard Strominger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 26},
  pages={14642-7}
}
The peptides bound to class II major histocompatibility complex (MHC) molecules extend out both ends of the peptide binding groove. This structural feature provided the opportunity to design multivalent polypeptide chains that cross-link class II MHC molecules through multiple, repetitive MHC binding sites. By using recombinant techniques, polypeptide oligomers were constructed that consist of up to 32 copies of an HLA-DR1-restricted T cell epitope. The epitope HA306-318, derived from influenza… CONTINUE READING