Superactivated platelets: thrombus regulators, thrombin generators, and potential clinical targets.

@article{Mazepa2013SuperactivatedPT,
  title={Superactivated platelets: thrombus regulators, thrombin generators, and potential clinical targets.},
  author={Marshall A Mazepa and M. Hoffman and Dougald M Monroe},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 8},
  pages={1747-52}
}
Platelets contribute to hemostasis by forming the platelet plug and then contributing to coagulation by providing a catalytic surface where thrombin generation occurs efficiently. This catalytic activity, known as the platelet procoagulant response, is being recognized as a nuanced response. This review examines platelets' response to strong stimuli, which results in the formation of a platelet subpopulation (superactivated platelets) with several unique properties, including enhanced… CONTINUE READING

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