Super-resolution localization microscopy of radiation-induced histone H2AX-phosphorylation in relation to H3K9-trimethylation in HeLa cells.

@article{Hausmann2018SuperresolutionLM,
  title={Super-resolution localization microscopy of radiation-induced histone H2AX-phosphorylation in relation to H3K9-trimethylation in HeLa cells.},
  author={Michael Hausmann and Emma Wagner and Jin-Ho Lee and Gerrit Schrock and Wladimir Schaufler and Matthias Krufczik and Franziska Papenfu\ss and Matthias Port and Felix Bestvater and Harry Scherthan},
  journal={Nanoscale},
  year={2018},
  volume={10 9},
  pages={
          4320-4331
        }
}
Ionizing radiation (IR)-induced damage confers functional and conformational changes to nuclear chromatin associated with DNA single and double strand breaks. This leads to the activation of complex DNA repair machineries that aim to preserve the integrity of the DNA molecule. Since hetero- and euchromatin are differentially accessible to DNA repair… CONTINUE READING