Super-induction of HO-1 in macrophages stimulated with lipopolysaccharide by prior depletion of glutathione decreases iNOS expression and NO production.

@article{Srisook2005SuperinductionOH,
  title={Super-induction of HO-1 in macrophages stimulated with lipopolysaccharide by prior depletion of glutathione decreases iNOS expression and NO production.},
  author={Klaokwan Srisook and Y. -N. Cha},
  journal={Nitric oxide : biology and chemistry},
  year={2005},
  volume={12 2},
  pages={70-9}
}
In the LPS-stimulated macrophages undergoing oxidative burst, intracellular storage of glutathione (GSH) is depleted, expression of iNOS is enhanced, and NO is overproduced. In response to the depletion of GSH, expression of HO-1 is induced and HO activity is elevated. Thus, in macrophages treated with LPS, productions of NO and CO, catalyzed, respectively, by accumulated iNOS and HO-1, are increased in sequence [Biochem. Pharmacol. 68 (2004) 1709]. In support of this, HO-1 is induced in… CONTINUE READING
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