Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation.

@article{Faessel1998SuperIV,
  title={Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation.},
  author={H{\'e}l{\`e}ne M. Faessel and Harry K. Slocum and Russell C. Jackson and Theodore J. Boritzki and Youcef M. Rustum and Muraleedharan G Nair and William R. Greco},
  journal={Cancer research},
  year={1998},
  volume={58 14},
  pages={3036-50}
}
The combined action among polyglutamylatable and nonpolyglutamylatable antifolates, directed against dihydrofolate reductase (DHFR), glycinamide ribonucleotide formyltransferase (GARFT), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), and thymidylate synthase (TS), in human ileocecal HCT-8 cells was examined in a 96-well plate… CONTINUE READING