Super-additive interaction of the reinforcing effects of cocaine and H1-antihistamines in rhesus monkeys.


Histamine H1 receptor antagonists can be sedating and have behavioral effects, including reinforcing and discriminative stimulus effects in non-humans, that predict abuse liability. Previous research has suggested that antihistamines can enhance the effects of some drugs of abuse. We have reported a synergistic interaction between cocaine and… (More)
DOI: 10.1016/j.pbb.2008.09.013


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