Sunlight‐induced mutagenicity of a common sunscreen ingredient

@article{Knowland1993SunlightinducedMO,
  title={Sunlight‐induced mutagenicity of a common sunscreen ingredient},
  author={John Knowland and Edward A Mckenzie and Peter J. McHugh and Nigel Cridland},
  journal={FEBS Letters},
  year={1993},
  volume={324}
}
Characterization of DNA Damage Inflicted by Free Radicals from a Mutagenic Sunscreen Ingredient and Its Location Using an in vitro Genetic Reversion Assay
TLDR
Using a genetic reversion assay that depends on regenerating P‐galactosidase activity in photodamaged plas‐mids, it is found that GC base pairs are particularly susceptible to attack by Padimate‐O.
Benzophenone and Padimate-O Protect Saccharomyces cerevisiae From UV Radiation and Cause Little Harm From UV-Induced Reactive Chemical Species
TLDR
The protection provided for Saccharomyces cerevisiae by two sunscreen chemicals, padimate-O and benzophenone, during a UV light survival assay outweighed potential negative effects that the chemicals may have had.
The Photochemical Potential of Some Sunscreens to Damage DNA
TLDR
In the case of human skin tumors, application of the polymerase chain reaction has made it possible to describe the mutations found in the P53 tumor suppressor gene in the clinical specimens that have been removed from patients undergoing surgery.
Photoprotection of DNA (in vitro) by acyclothymidine dinucleosides.
Photosensitization of the Sunscreen Octyl p‐Dimethylaminobenzoate by UVA in Human Melanocytes but not in Keratinocytes ¶
TLDR
The results indicate that sunscreens may increase cell mobility and the combination of o‐PABA with solar UV may selectively damage melanocytes in the skin.
Protection by ultraviolet A and B sunscreens against in situ dipyrimidine photolesions in human epidermis is comparable to protection against sunburn.
TLDR
The ability of two sunscreens, with different spectral profiles, to inhibit DNA photodamage in human epidermis in situ, is assessed to indicate similar action spectra for erythema and DNA photODamage and that ery thema is a clinical surrogate for DNAPhotodamages that may lead to skin cancer.
Sunscreens inadequately protect against ultraviolet-A-induced free radicals in skin: implications for skin aging and melanoma?
TLDR
The disparity between these protection factors suggests that prolonged sunbathing (encouraged by use of these creams) would disproportionately increase exposure to ultraviolet A and consequently the risk of ultraviolet-A-related skin damage.
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While estimates of the effectiveness of all products were much too high when calculated by the isopropanol solution method, the hairless mouse epidermis technique seems to be an accurate tool for predicting product efficacy in vivo.
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Abstract— The photochemical reactions of benzophenone and acetophenone with purine and pyrimidine derivatives in aqueous solutions have been investigated by flash photolysis and steady‐state
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