Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need?

@article{Holick2020SunlightUR,
  title={Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need?},
  author={Michael F Holick},
  journal={Advances in experimental medicine and biology},
  year={2020},
  volume={1268},
  pages={
          19-36
        }
}
  • M. Holick
  • Published 2020
  • Medicine
  • Advances in experimental medicine and biology
Vitamin D is the sunshine vitamin for good reason. During exposure to sunlight, the ultraviolet B photons enter the skin and photolyze 7-dehydrocholesterol to previtamin D3 which in turn is isomerized by the body's temperature to vitamin D3. Most humans have depended on sun for their vitamin D requirement. Skin pigment, sunscreen use, aging, time of day, season, and latitude dramatically affect previtamin D3 synthesis. Vitamin D deficiency was thought to have been conquered, but it is now… 
5 Citations
Lessons Learned from Paleolithic Models and Evolution for Human Health: A Snap Shot on Beneficial Effects and Risks of Solar Radiation.
  • J. Reichrath
  • Medicine
    Advances in experimental medicine and biology
  • 2020
TLDR
This chapter summarizes the content of the third edition of "Sunlight, Vitamin D and Skin Cancer," a book specifically designed and organized to be an up-to-date review covering the most important aspects of the ongoing debate on how much sun is good for human health and how to balance between the positive and negative effects of solar and artificial UV-radiation.
Vitamin D and Cardiovascular Disease: An Updated Narrative Review
TLDR
There is no strong evidence for beneficial vitamin D effects on CVD risk, either in the general population or in high-risk groups, and whether some subgroups such as individuals with severe vitamin D deficiency or a combination of low vitamin D status with specific gene variants and/or certain nutrition/lifestyle factors would benefit from vitamin D (metabolite) administration remains to be studied.
The Exposome and Immune Health in Times of the COVID-19 Pandemic
TLDR
The potential role of ‘exposome improvements’ in the prevention—or amelioration, once established—of this disease as well as their effect on the response to vaccination are highlighted.
Infantile urolithiasis
TLDR
A prospective cohort and case-control study on 30 infants with urolithiasis and 30 healthy control infants, all 60 being exclusively breastfed and all receiving daily standard supplementation with oral vitamin D, found that hypercalciuria has been reported as the most frequent metabolic abnormality.
Prenatal exposure to solar radiation and hypertensive disorders of pregnancy
TLDR
To examine the association between prenatal exposure to solar radiation and hypertensive disorders of pregnancy (HDP), a large number of women were diagnosed with at least one of the following conditions during pregnancy: high blood pressure, high blood sugar, or both.

References

SHOWING 1-10 OF 90 REFERENCES
Sunlight and Vitamin D
TLDR
A three-part strategy of increasing food fortification programs with vitamin D, sensible sun exposure recommendations and encouraging ingestion of a vitamin D supplement when needed should be implemented to prevent global vitamin D deficiency and its negative health consequences.
Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin.
TLDR
The dramatic influence of changes in solar UVB radiation on cutaneous vitamin D3 synthesis is quantified and the latitudinal increase in the length of the "vitamin D winter" during which dietary supplementation of the vitamin may be advisable is indicated.
Vitamin D and Skin Physiology: A D‐Lightful Story
TLDR
The associations regarding increased risk of common deadly cancers, autoimmune diseases, infectious diseases, and cardiovascular disease with living at higher latitudes and being prone to vitamin D deficiency should alert all health care professionals about the importance of vitamin D for overall health and well being.
The vitamin D questions: how much do you need and how should you get it?
Sunscreens suppress cutaneous vitamin D3 synthesis.
TLDR
Results indicate that the sunscreen interferred with the cutaneous production of vitamin D3, and prevented the photoisomerization of 7-dehydrocholesterol to previtamin D3 in human skin slices in vitro.
Solar radiation and human health.
TLDR
What is known about spectral and intensity variations of terrestrial solar radiation as well as its penetration through the atmosphere and into human skin and tissue and action spectra relevant for health are described.
Ultraviolet B Light Emitting Diodes (LEDs) Are More Efficient and Effective in Producing Vitamin D3 in Human Skin Compared to Natural Sunlight
TLDR
This work has significant health implications for medical device development in the future that can be used for providing vitamin D supplementation to patients with fat malabsorption syndromes as well as patients with other metabolic abnormalities including patients with chronic kidney disease.
Can you have your cake and eat it too? The sunlight D‐lema
  • M. Holick
  • Medicine
    The British journal of dermatology
  • 2016
In this issue of the BJD, Felton et al. report the results of their elegantly designed study to determine the impact on vitamin D status and skin DNA damage for healthy adults with skin types 2 and 5
Resurrection of vitamin D deficiency and rickets.
  • M. Holick
  • Medicine
    The Journal of clinical investigation
  • 2006
TLDR
This review summarizes the role of vitamin D in the prevention of rickets and its importance in the overall health and welfare of infants and children.
...
1
2
3
4
5
...