Sunitinib in solid tumors

@article{Gan2009SunitinibIS,
  title={Sunitinib in solid tumors},
  author={Hui Kong Gan and Bo{\vs}tjan {\vS}eruga and Jennifer J. Knox},
  journal={Expert Opinion on Investigational Drugs},
  year={2009},
  volume={18},
  pages={821 - 834}
}
  • H. GanB. ŠerugaJ. Knox
  • Published 25 May 2009
  • Medicine, Biology, Chemistry
  • Expert Opinion on Investigational Drugs
Background: Until recently, few treatments were available for renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GIST). Several targeted agents inhibiting key pathogenetic pathways have since been developed for RCC (sunitinib, sorafenib, bevacizumab, temsirolimus, everolimus) and GIST (imatinib, sunitinib). Sunitinib is a multi-kinase inhibitor of VEGFR-2, PDGFR (α,β), FLT-3, KIT, CSF-1 and RET. Objective: To summarize the literature regarding the structure, pharmacokinetics… 

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