Sunitinib in pancreatic neuroendocrine tumors: updated progression-free survival and final overall survival from a phase III randomized study.

@article{Faivre2016SunitinibIP,
  title={Sunitinib in pancreatic neuroendocrine tumors: updated progression-free survival and final overall survival from a phase III randomized study.},
  author={Sandrine J. Faivre and Patricia Niccoli and Daniel E. Castellano and Juan W Valle and Pascal Hammel and Jean-Luc Raoul and Aaron I Vinik and Eric Van Cutsem and Y. -J. Bang and Sang-Ho Lee and Ivan Borbath and C Lombard-bohas and Peter P Metrakos and Denis Smith and J C Chen and Philippe B Ruszniewski and J F Seitz and Shem Patyna and Dongrui Ray Lu and Khajak J. Ishak and Eric Raymond},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2016},
  volume={28 2},
  pages={339-343}
}
Background In a phase III trial in patients with advanced, well-differentiated, progressive pancreatic neuroendocrine tumors, sunitinib 37.5 mg/day improved investigator-assessed progression-free survival (PFS) versus placebo (11.4 versus 5.5 months; HR, 0.42; P < 0.001). Here, we present PFS using retrospective blinded independent central review (BICR) and final median overall survival (OS), including an assessment highlighting the impact of patient crossover from placebo to sunitinib… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
11 Citations
20 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

May 2007)

  • US Food, Drug Administration. Guidance for Industry Clinical Tri Drugs, Biologics. 2007 last update
  • Available online at: http://www.fda.gov/downloads…
  • 2016
1 Excerpt

Updated results from a phase III trial of sunitinib versus placebo in patients with progressive, unresectable, well-differentiated pancreatic neuroendocrine tumor (NET)

  • A CEVinik, P. Niccoli
  • 48th Annual Meeting of the American Society of…
  • 2012

Similar Papers

Loading similar papers…