Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer.

@article{Stewart2015SunitinibTE,
  title={Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer.},
  author={Grant S Stewart and Fiach C. O'Mahony and Alexander Laird and L{\'e}l Eory and Alexander L.R. Lubbock and Alan Mackay and Jyoti Nanda and Marie O'Donnell and Penelope M. Mullen and Stuart Mcneill and Antony C. P. Riddick and Daniel Berney and Axel Bex and M. J. K. Aitchison and Ian M. Overton and David J. Harrison and Thomas B Powles},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2015},
  volume={21 18},
  pages={
          4212-23
        }
}
PURPOSE The aim of this study was to investigate the effect of VEGF-targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). EXPERIMENTAL DESIGN Multiple tumor samples (n = 187 samples) were taken from the primary renal tumors of patients with mccRCC who were sunitinib treated (n = 23, SuMR clinical trial) or untreated (n = 23, SCOTRRCC study). ITH of pathologic grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate… CONTINUE READING
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