Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma.

@article{Mjean2018SunitinibAO,
  title={Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma.},
  author={Arnaud M{\'e}jean and Alain Ravaud and Simon Th{\'e}z{\'e}nas and S. Navarro Col{\'a}s and J. B. Beauval and Karim Bensalah and Lionnel Geoffrois and Antoine Thiery-vuillemin and L. Sherilyn Cormier and Herv{\'e} Lang and Lawrence D. Guy and Gw{\'e}naelle Gravis and Fr{\'e}d{\'e}ric Rolland and Claude Linassier and {\'E}ric Lechevallier and Christian Beisland and Michael Aitchison and St{\'e}phane Oudard and Jean-Jacques Patard and Christine Th{\'e}odore and Christine Chevreau and Brigitte Laguerre and Jacques Hubert and Marine Gross-Goupil and J. Bernhard and Laurence K Albiges and Martine Timsit and Thierry Lebr{\'e}t and Bernard Escudier},
  journal={The New England journal of medicine},
  year={2018},
  volume={379 5},
  pages={
          417-427
        }
}
BACKGROUND Cytoreductive nephrectomy has been the standard of care in metastatic renal-cell carcinoma for 20 years, supported by randomized trials and large, retrospective studies. However, the efficacy of targeted therapies has challenged this standard. We assessed the role of nephrectomy in patients with metastatic renal-cell carcinoma who were receiving targeted therapies. METHODS In this phase 3 trial, we randomly assigned, in a 1:1 ratio, patients with confirmed metastatic clear-cell… CONTINUE READING

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