Sunburn, sunscreens, and phenotypes: some risk factors for cutaneous melanoma in southern Brazil

  title={Sunburn, sunscreens, and phenotypes: some risk factors for cutaneous melanoma in southern Brazil},
  author={L{\'u}cio Bakos and Mario Wagner and Renato Marchiori Bakos and C S Leite and Cristina L. Sperhacke and Karina S Dzekaniak and Ana Gleisner},
  journal={International Journal of Dermatology},
Background The risk factors for cutaneous malignant melanoma have been studied in populations from numerous countries around the world. There are no published studies on the risk factors for this malignancy in Brazil, the largest country in South America. 

Is season important for the diagnosis of cutaneous melanoma in southern Brazil? A 10‐year hospital‐based study

In several countries, more cases of CM are diagnosed in summer than in winter, and exposure to sunlight is an important etiologic factor in cutaneous melanoma.

European ancestry and cutaneous melanoma in Southern Brazil

The skin of the Brazilian population presents all phototypes, being progressively lighter following the increase of the latitude toward the South, where the highest incidence of melanoma is observed.

Risk factors for developing cutaneous melanoma in Santa Catarina, Brazil: a case-control observational study

Methods: Case-control observational study of 518 people in western Santa Catarina, including 259 patients diagnosed with CM between 2002 and 2012, and 259 age-, sex, and residence-matched controls.

Genetic variations of patients with familial or multiple melanoma in Southern Brazil

Background  Patients with familial melanoma or multiple primary melanoma represent a high‐risk population to hereditary melanoma. Mutations in susceptibility genes, such as CDKN2A, CDK4 and MC1R,

Distribution of clinical‐pathological types of cutaneous melanomas and mortality rate in the region of Passo Fundo, RS, Brazil

The characteristics of all cases of primary cutaneous melanoma during the period 1995–2001, registered at pathology departments in the region of Passo Fundo are described.

Use of sunscreen and risk of melanoma and non-melanoma skin cancer: a systematic review and meta-analysis

The current evidence suggests no increased risk of skin cancer related to sunscreen use, but this systematic review and meta-analysis does not confirm the expected protective benefits of sunscreen against skin cancer in the general population.

Sunscreen Use and the Risk for Melanoma: A Quantitative Review

This meta-analysis of 18 casecontrol studies found no good evidence for an increased risk for melanoma with sunscreen use, and the strength and the consistency of the observed associations between melanoma and sunscreen use were examined.

Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure.

Early diagnosis of cutaneous melanoma: an observation in southern Brazil.

The profile of cases of cutaneous melanoma diagnosed in a tertiary hospital seems to be experiencing some changes over the last two decades, with a current trend for earlier diagnosis.



Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma: Western Canada Melanoma Study.

Comparisons of case-control pairs showed that light hair colour was the strongest risk factor for the disease and were consistent with other studies reporting associations between melanoma and poor tanning ability, a tendency to burn easily, and a history of sunburn.

Malignant melanoma: aetiological importance of individual pigmentation and sun exposure.

The results suggest that in a population of Caucasian origin with a predominantly fair complexion, pigmentary status characterized by hair colour is a far more important aetiological factor than sun habits.

Epidemiological Support for an Hypothesis for Melanoma Induction Indicating a Role for UVA Radiation

It is likely that UVA, being absorbed by melanin, might have a melanoma‐inducing effect, and this is in agreement with some epidemiological investigations which indicate that sun‐screen lotions may not protect sufficiently against melanoma induction.

Malignant melanoma in England: risks associated with naevi, freckles, social class, hair colour, and sunburn.

Freckling and social class as well as naevi are strong and independent risk indicators for melanoma, although the social class gradient was observed neither for nodular melanoma nor for melanomas occurring on the most exposed body sites.

Geographical distribution of cutaneous melanoma in Queensland

There was a significantly increased incidence of melanoma in coastal, compared to inland, regions in Queensland, and the observed regional differences in incidence may yet be explained by the variation in actual exposure to ultraviolet radiation received by the population.

Habits of sun exposure and risk of malignant melanoma: An analysis of incidence rates in Norway 1955–1977 by cohort, sex, age, and primary tumor site

The incidence of malignant melanoma per area unit of skin was greater for the trunk and lower limb than for the face‐neck, suggesting that not only the cumulated dose, but also the intensity of solar radiation may be significant in the cause of malign melanoma.

Wavelengths effective in induction of malignant melanoma.

The results are interpreted as indicating that light energy absorbed in melanin is effective in inducing melanomas in this animal model and that, in natural sunlight, 90-95% of melanoma induction may be attributed to wavelengths > 320 nm--the UV-A and visible spectral regions.

Incidence of cutaneous malignant melanoma in Denmark 1978-1982. Anatomic site distribution, histologic types, and comparison with non-melanoma skin cancer.

In a population based case series of 551 patients with malignant melanoma of the skin diagnosed in the period 1982 to 1985 collected as part of a population-based case-control study, the specific anatomic site of the primary lesion was recorded, and the lesions were classified as to histologic subtype.

Temporal trends in the incidence of cutaneous malignant melanoma among Caucasians in the San Francisco-Oakland MSA

The temporal patterns of CMM suggest that the recent increases are not accounted for solely by ascertainment bias due to reporting practices, and are consistent with early detection efforts and with changes in the prevalence of risk factors.