Sun protection in a pill: the photoprotective properties of Polypodium leucotomos extract

@article{ElHaj2015SunPI,
  title={Sun protection in a pill: the photoprotective properties of Polypodium leucotomos extract},
  author={Nura El-Haj and Norman P. Goldstein},
  journal={International Journal of Dermatology},
  year={2015},
  volume={54}
}
Physical blocks (i.e. wearing appropriate clothing), exposure avoidance, and the use of sunscreens are the main methods of photoprotection currently used. However, phytochemical and natural botanical extracts such as polypodium leucotomos, a tropical fern found in Central and South America, demonstrate a strong potential as adjuncts to sunscreen protection. 

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A thorough overview of research completed with Polypodium leucotomas extract is provided and suggested approaches for clinical use are outlined.

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A thorough overview of research completed with Polypodium leucotomas extract is provided and suggested approaches for clinical use are outlined.

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Comparative effects of a fixed Polypodium leucotomos/Pomegranate combination versus Polypodium leucotomos alone on skin biophysical parameters.

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Alternative Systemic Treatments for Vitiligo: A Review

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References

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Mechanistic insights in the use of a Polypodium leucotomos extract as an oral and topical photoprotective agent.

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TLDR
Recent evidence on the cellular and molecular mechanisms underlying the photoprotective effect of a Polypodium leucotomos fern extract postulate PL as a natural photoprotsective agent and a potential adjuvant to phototherapy for various skin diseases.

Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model

TLDR
The results demonstrate the efficacy of PL as an oral antioxidant and photoimmunoprotective agent and support its employment as a complement to topical sunscreens.

Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers

TLDR
Fernblock is an all-natural antioxidant extract administered both topically (on the skin) or orally and postulate its use as a novel-generation photoprotective nutriceutical of phytochemical origin.

Photoprotective activity of oral polypodium leucotomos extract in 25 patients with idiopathic photodermatoses

TLDR
This poster focuses on the treatment of idiopathic photodermatoses with a single excisional excision and aims to provide a simple, straightforward and effective procedure to correct the underlying cause of IP.

An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model: A pilot study

TLDR
The results of this preliminary study illustrate that PL treatment helped to ameliorate and to partially inhibit some of the histologic damage associated with photoaging of skin and appeared to contribute to a decrease in the prevalence of UVB‐induced skin tumors in mice.

Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen‐induced phototoxic reactions as well as depletion of Langerhans cells in human skin

TLDR
Photoprotective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photoprotection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such phototherapies.