Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis.

@article{Chen2011SumoylationpromotedE7,
  title={Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis.},
  author={Shu-Chuan Chen and L Z Chang and Yi-wei Wang and Yi-chun Chen and Kuo-Feng Weng and Shin-Ru Shih and Hsiu-ming Shih},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 36},
  pages={31373-84}
}
Enterovirus 71 (EV71), a member of the Picornaviridae family, may cause serious clinical manifestations associated with the central nervous system. Enterovirus 3C protease is required for virus replication and can trigger host cell apoptosis via cleaving viral polyprotein precursor and cellular proteins, respectively. Although the role of the 3C protease in processing viral and cellular proteins has been established, very little is known about the modulation of EV71 3C function by host cellular… CONTINUE READING

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