Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxbeta.

@article{Liu2006SumoylationOR,
  title={Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxbeta.},
  author={S Liu and Wen-Hung Wang and Yi-Ren Hong and Jian-Ying Chuang and P. Lu and L. -Sh. Chang},
  journal={Virus research},
  year={2006},
  volume={119 2},
  pages={163-70}
}
Epstein-Barr virus (EBV) expresses an immediate-early protein, Rta, to activate the viral lytic cycle. This study identifies PIASxalpha and PIASxbeta as binding partners of Rta in a yeast two-hybrid screen and demonstrates the binding of Rta to PIASxalpha and PIASxbeta in vitro by GST pull-down analysis. Coimmunoprecipitation experiments and indirect immunofluorescence analysis show that Rta interacts and colocalizes with PIASxalpha and PIASxbeta in the nucleus. These interactions seem to… CONTINUE READING
Highly Cited
This paper has 29 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…