Sumoylation: a regulatory protein modification in health and disease.

@article{Flotho2013SumoylationAR,
  title={Sumoylation: a regulatory protein modification in health and disease.},
  author={Annette Flotho and Frauke Melchior},
  journal={Annual review of biochemistry},
  year={2013},
  volume={82},
  pages={357-85}
}
Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly, protein homeostasis, trafficking, and signal transduction are subject to reversible sumoylation. Hence, it is not surprising that disease links are beginning to emerge and that interference with… CONTINUE READING
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