Sumoylation: a regulatory protein modification in health and disease.

  title={Sumoylation: a regulatory protein modification in health and disease.},
  author={Annette Flotho and Frauke Melchior},
  journal={Annual review of biochemistry},
Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly, protein homeostasis, trafficking, and signal transduction are subject to reversible sumoylation. Hence, it is not surprising that disease links are beginning to emerge and that interference with… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
196 Citations
210 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 196 extracted citations


Publications referenced by this paper.
Showing 1-10 of 210 references

Similar Papers

Loading similar papers…