Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes.

@article{Gupta2014SumoEE,
  title={Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes.},
  author={Manish K. Gupta and James Gulick and Ruijie Liu and Xuejun Wang and Jeffery D Molkentin and Jeffrey Robbins},
  journal={Circulation research},
  year={2014},
  volume={115 8},
  pages={721-9}
}
RATIONALE Impairment of proteasomal function is pathogenic in several cardiac proteinopathies and can eventually lead to heart failure. Loss of proteasomal activity often results in the accumulation of large protein aggregates. The ubiquitin proteasome system (UPS) is primarily responsible for cellular protein degradation, and although the role of… CONTINUE READING