Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance.

@article{Loftus2009Sumo23ylationFI,
  title={Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance.},
  author={Liam T Loftus and Rosaria Gala and Tao Yang and Veronica Joy Jessick and Michelle Dawn Ashley and Andrea Nicole Ordonez and Simon John Thompson and Roger Simon and Robert Meller},
  journal={Brain research},
  year={2009},
  volume={1272},
  pages={71-80}
}
Several recent studies suggest that sumo-2/3 modification of proteins occurs following harmful ischemia, however, sumo-2/3-ylation may also be associated with hibernation-mediated neuroprotection. Here we investigate the sumoylation of proteins following ischemia and ischemic tolerance using our established in vitro model of ischemia (oxygen and glucose deprivation; OGD). Following harmful ischemia (120 min OGD), we observed a significant increase in the sumo-2/3-ylation of high molecular… CONTINUE READING

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