Summary p 25 / Cdk 5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death

Cell mechanisms that lead to apoptosis share some pathways with cell proliferation. This feature is even more surprising in differentiated cells such as neurons, in which it was suggested that a reactivation of the cell cycle is a key step towards apoptosis (Copani et al., 2001). In fact, neurons of the adult brain are in G0 phase: they do not divide and… CONTINUE READING