• Corpus ID: 7440195

Summary of probiotics effects on epithelial barrier function in vitro and in vivo

@inproceedings{Ohland2010SummaryOP,
  title={Summary of probiotics effects on epithelial barrier function in vitro and in vivo},
  author={Christina L Ohland and Wallace K. MacNaughton},
  year={2010}
}
Ohland CL, MacNaughton WK. Probiotic bacteria and intestinal epithelial barrier function. Am J Physiol Gastrointest Liver Physiol 298: G807–G819, 2010. First published March 18, 2010; doi:10.1152/ajpgi.00243.2009.—The intestinal tract is a diverse microenvironment where more than 500 species of bacteria thrive. A single layer of epithelium is all that separates these commensal microorganisms and pathogens from the underlying immune cells, and thus epithelial barrier function is a key component… 

Figures and Tables from this paper

References

SHOWING 1-10 OF 166 REFERENCES

Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC)

TLDR
Live ST/LA interact with intestinal epithelial cells to protect them from the deleterious effect of EIEC via mechanisms that include, but are not limited to, interference with pathogen adhesion and invasion.

Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function.

Live probiotic bacteria are effective in reducing gut permeability and inflammation. We have previously shown that probiotics release peptide bioactive factors that modulate epithelial resistance in

The mechanism of action of probiotics

TLDR
Support is marshalled for the concept that administration of probiotics ameliorates inflammation by exerting positive effects on the epithelial cell dysfunction and mucosal immune system dysfunction that forms the basis of the inflammation.

Mechanisms of action of probiotics: Recent advances

TLDR
Mechanisms contributing to altered immune function in vivo induced by probiotic bacteria may include modulation of the microbiota itself, improved barrier function with consequent reduction in immune exposure to microbiota, and direct effects of bacteria on different epithelial and immune cell types.

Functional modulation of enterocytes by gram-positive and gram-negative microorganisms.

  • J. OtteD. Podolsky
  • Biology
    American journal of physiology. Gastrointestinal and liver physiology
  • 2004
TLDR
Probiotics and protein(s) released by these organisms may functionally modulate the intestinal epithelium of the host by different mechanisms, including the competition of whole organisms for contact with the epithelial surface as well as stabilization of the cytoskeleton and barrier function and the induction of mucin expression.

The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

TLDR
Whether the cells producing mucins or antimicrobial peptides and the resident microbiota act in partnership and whether they function individually and/or synergistically to provide the host with an effective front line of defense against harmful enteric pathogens is examined.

Probiotic bacteria enhance murine and human intestinal epithelial barrier function.

TLDR
In vitro studies showed that epithelial barrier function and resistance to Salmonella invasion could be enhanced by exposure to a proteinaceous soluble factor secreted by the bacteria found in the VSL#3 compound.

Inhibition of Escherichia coli O157:H7 attachment by interactions between lactic acid bacteria and intestinal epithelial cells.

TLDR
Results indicate that MUC2 mucin and cytokines are important regulatory factors in the immune systems of the gut, and that selected lactobacilli may be able to induce the upregulation of M UC2 mucIn and specific cytokines, thereby inhibiting the attachment of E. coli O157:H7.

Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad.

  • M. ChichlowskiL. Hale
  • Biology, Medicine
    American journal of physiology. Gastrointestinal and liver physiology
  • 2008
TLDR
The complex structure of the epithelial barrier is described in the context of bacterial-mucosal interactions observed in human IBD and mouse models of colitis.

Probiotics and Commensals Reverse TNF-α– and IFN-γ–Induced Dysfunction in Human Intestinal Epithelial Cells

Background & Aims: Commensal bacteria are crucial for the development of the mucosal immune system. Probiotics are commensals with special characteristics and may protect mucosal surfaces against
...