Summary of Consensus Statement on Intersex Disorders and Their Management

  title={Summary of Consensus Statement on Intersex Disorders and Their Management},
  author={Christopher P. Houk and Ieuan A. Hughes and S. Faisal Ahmed and Peter A. Lee},
  pages={753 - 757}
Advances in understanding of genetic control of sexual determination and differentiation, improvements in diagnostic testing and surgical genital repair, and the persistent controversies inherent to clinical management were all compelling factors that led to the organization of an international consensus conference. The goals were to acknowledge and discuss the more controversial issues in intersex management, provide management guidelines for intersex patients, and identify and prioritize… 

How should we classify intersex disorders?


The medical conditions where infants may be born with ambiguous genitalia leading to decisions with regard to gender assignment, and the approach to investigations and diagnosis in the newborn period will be stressed within an interprofessional team.

Genetic evaluation of children with ambiguous genitalia

Early identification of the genetic cause of DSD will in many cases streamline and direct clinical management of the patient with more focused endocrine and imaging studies and better surgical decision.

Consensus Statement on Terminology and Management: Disorders of Sex Development

Conclusions were reached that genital surgery should be performed for the infant with significant ambiguity, in spite of the lack of outcome data, when the parents unequivocally desire and that desired outcome data will not be available for decades, if ever.

[Disorders of sex differentiation: state of the problem 15 years after the Chicago consensus].

Recommendations regarding gender reassignment and appropriate early surgical treatment have been completely ignored in some countries and were largely facilitated by the confrontational activities of a number of support groups.

Disorders of sex development: a new definition and classification.

  • I. Hughes
  • Medicine
    Best practice & research. Clinical endocrinology & metabolism
  • 2008

Standards of Care for Congenital Adrenal Hyperplasia: a Call for Change in the Caribbean Region

Given the lack of international agreement and based on long-term outcome data on gender expressions among 46, XX CAH individuals, it is advocated for a Caribbean social policy that prioritizes the right to live gender as chosen by individuals born with genital variance.

A review of the essential concepts in diagnosis, therapy, and gender assignment in disorders of sexual development

The aim of this article is to review the essential concepts, current terminologies and classification, management guidelines and the rationale of gender assignment in different types of



A Perspective on the Approach to the Intersex Child Born with Genital Ambiguity

  • Peter A. Lee
  • Medicine
    Journal of pediatric endocrinology & metabolism : JPEM
  • 2004
It is clear that care of the child with genital ambiguity must be individualized, with parents and patients regularly receiving updated information concerning the etiology, treatment and outcome among children with similar diagnoses.

Consensus Statement on Management of Intersex Disorders

The Lawson Wilkins Paediatric Endocrine Society (LWPES) and the EPE considered it timely to review the management of intersex disorders from a broad perspective, to review data on longer term outcome and to formulate proposals for future studies.

Aetiological diagnosis of male sex ambiguity: a collaborative study

Hormonal tests may help to discriminate between partial androgen insensitivity and gonadal dysgenesis/true hermaphroditism but are of less use for differentiating from unexplained male pseudohermaphrodites.

Changing the Nomenclature/Taxonomy for Intersex: A Scientific and Clinical Rationale

We explain here why the standard division of many intersex types into true hermaphroditism, male pseudohermaphroditism, and female pseudohermaphroditism is scientifically specious and clinically

Attitudes of adult 46, XY intersex persons to clinical management policies.

The majority of adult patients with intersexuality appeared to be satisfied with gender and genital status, and did not support major changes in the prevailing policy, however, a significant minority was dissatisfied and endorsed policy changes.

Feminizing surgical management of intersex patients

The study’s objective was to evaluate the results of surgical modalities for children with ambiguous genitalia and found that it is possible to obtain a better cosmetic and functional result with an easier technique.

Testicular Intratubular Germ Cell Neoplasia in Children and Adolescents with Intersex

In a review of 102 cases with various intersex states, the frequency of intratubular germ cell neoplasia unclassified in testes of children and adolescents was 6%, and the atypical germ cells in all testes with IGCN showed immunoreactivity with placental alkaline phosphatase.

Ambiguous genitalia with perineoscrotal hypospadias in 46,XY individuals: long-term medical, surgical, and psychosexual outcome.

Either male or female sex of rearing can lead to successful long-term outcome for the majority of cases of severe genital ambiguity in 46,XY individuals.

Hormonal therapies for individuals with intersex conditions: protocol for use.

A vigorous debate about ethical aspects of current medical practices relating to intersex conditions has been waged for the last 7 years between certain patient advocacy organizations and the medical profession, and is expected to continue for some time.

Ethics and Intersex

This book discusses intersexuality, Cultural Influences and Cultural Relativism, Christianity and Human Sexual Polymorphism, and the role of genes and Hormones in Sexual Differentiation in Christianity and Intersexuality.