Summary and Conclusions

  • Published 2008


Coeliac disease (CD) is a disorder of children and adults manifested by characteristic abnormalities of the small-intestinal mucosa that results from a permanent, genetically and immunologically based intolerance to ingested gluten. Clinical, serological and histological improvements commonly follow withdrawal of dietary gluten. Recent studies from Europe, North America and many other countries have shown a prevalence of 1 in 80 to 1 in 140 in the general population. In the Netherlands a prevalence of 1 in 198 has been reported. Numerous diagnostic tools have evolved over the years to identify CD, the chameleon. The techniques have been either improved or innovated to detect the disease or its complications. The thesis acknowledges the application and the impact of several tools in this entity. The historical developments of various tools are presented in section I. Despite the diversity of these tools, no one could prove optimal to, or substitute the gold standard based on small bowel histology for the diagnosis of CD. The discovery and widespread use of serum antibody tests actually formed the main contributing factor to revise the diagnostic definition criteria of CD by excluding a follow-up biopsy and gluten challenge from the original list. However, the value of these simple, cheap and non-invasive assays declined when they were tested in clinical practice as

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@inproceedings{2008SummaryAC, title={Summary and Conclusions}, author={}, year={2008} }