Summary Metalloproteinase inhibitors : biological actions and therapeutic opportunities

  title={Summary Metalloproteinase inhibitors : biological actions and therapeutic opportunities},
  author={Andrew H. Baker and Dylan R W Edwards and Gillian Murphy},
Metalloproteinases (MPs) play key roles in the responses of cells to their microenvironment. By effecting proteolytic degradation or activation of cell surface and extracellular matrix (ECM) proteins they can modulate both cell-cell and cell-ECM interactions, which influence cell differentiation, migration, proliferation and survival. Both secreted and membranebound forms of metalloproteinases have been implicated in pericellular proteolysis, including the matrix metalloproteinases (MMPs), the… CONTINUE READING


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