Summarizing Probe Intensities of Affymetrix GeneChip 3' Expression Arrays Taking into Account Day-to-Day Variability

Abstract

Microarray experiments are affected by several sources of variability. The paper demonstrates the major role of the day-to-day variability, it underlines the importance of a randomized block design when processing replicates over several days to avoid systematic biases and it proposes a simple algorithm that minimizes the day dependence.

DOI: 10.1109/TCBB.2010.82

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Cite this paper

@article{Magni2011SummarizingPI, title={Summarizing Probe Intensities of Affymetrix GeneChip 3' Expression Arrays Taking into Account Day-to-Day Variability}, author={Paolo Magni and Angela Simeone and Sandra Healy and Antonella Isacchi and Roberta Bosotti}, journal={IEEE/ACM Transactions on Computational Biology and Bioinformatics}, year={2011}, volume={8}, pages={1425-1430} }