Sumatriptan succinate transdermal delivery systems for the treatment of migraine.

@article{BalaguerFernndez2008SumatriptanST,
  title={Sumatriptan succinate transdermal delivery systems for the treatment of migraine.},
  author={Cristina Balaguer-Fern{\'a}ndez and Andr{\'e}s Femen{\'i}a-Font and Sergio del R{\'i}o-Sancho and V. Baonza Merino and Alicia C L{\'o}pez-Castellano},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 6},
  pages={
          2102-9
        }
}
We have successfully obtained sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propylenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin… CONTINUE READING

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