Sumatriptan modifies cortical free radical release during cortical spreading depression. A novel antimigraine action for sumatriptan?

@article{Read2000SumatriptanMC,
  title={Sumatriptan modifies cortical free radical release during cortical spreading depression. A novel antimigraine action for sumatriptan?},
  author={Simon J Read and Andrew A. Parsons},
  journal={Brain research},
  year={2000},
  volume={870 1-2},
  pages={44-53}
}
Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and effective antimigraine therapy, on free radical release (nitric oxide and superoxide) in SD in the simple and complex cortices of the rat and cat. Following initiation of SD… CONTINUE READING

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Cortical spreading depression as a target for anti-migraine agents

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